There has been great progress in uncovering gene expression patterns that are clinically informative, and suggest pathway associations with disease. Nevertheless, two key challenges remain to translate these gene relationships to new diagnostics and ultimately to new therapies. The primary challenge is to establish a correlation between the prospective gene markers and their corresponding protein products, especially the subsets most relevant to clinical features of disease. A second challenge is to distill the most informative subset of genes to assayable biomarkers that can be readily measured from biological fluids using technologies common to clinical laboratories.

ProFACT's services assist gene expression researchers to overcome these challenges by providing:

Using a multidimensional proteomic approach, ProFACT will identify, quantify, and analyze predicted protein targets based on client-supplied gene expression data. Yellow Boxes are ProFACT service deliverables. Dashed lines indicate options available. A suitable handoff is made to applications in biomarker discovery, diagnostics, and drug development (orange boxes).