PLAU antibody - 100 µg
Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: plasminogen activator, urokinase
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 54 kDa
Uniprot: P00749
Gene id: 5328
Background: PLAU(Urokinase-type plasminogen activator) is also named as uPA and belongs to the peptidase S1 family.UPA initiates a proteolytic cascade, which degrades extracellular matrix during tissue growth and remodelling.The secreted proform of UPA is activated after binding to a specific high affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1(PAI-1), which is stored in the extracellular matrix bound to vitronectin(PMID:9665342).It has 2 isoforms produced by alternative splicing.Defects in PLAU are the cause of Quebec platelet disorder(QPD).
Field of research: Immunology, Cardiovascular, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP, IF
Dilution: WB: 1:500-1:1000; IHC:1:20-1:200;IF: 1:20-1:200; IP: 1:500-1:2000
Target: PLAU
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat
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Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: plasminogen activator, urokinase
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 54 kDa
Uniprot: P00749
Gene id: 5328
Background: PLAU(Urokinase-type plasminogen activator) is also named as uPA and belongs to the peptidase S1 family.UPA initiates a proteolytic cascade, which degrades extracellular matrix during tissue growth and remodelling.The secreted proform of UPA is activated after binding to a specific high affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1(PAI-1), which is stored in the extracellular matrix bound to vitronectin(PMID:9665342).It has 2 isoforms produced by alternative splicing.Defects in PLAU are the cause of Quebec platelet disorder(QPD).
Field of research: Immunology, Cardiovascular, Signal Transduction
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC, IP, IF
Dilution: WB: 1:500-1:1000; IHC:1:20-1:200;IF: 1:20-1:200; IP: 1:500-1:2000
Target: PLAU
Purification: Immunogen affinity purified
Reactivity: Human, Mouse, Rat