Reach The ProFACT Value Proposition in Personalized Medicine

                   

In the 'omics' universe today, each discipline independently prospects for biomarkers, but for reasons both technical and commercial, there is little crosstalk between the disciplines. Most importantly, the current 'omics' paradigm inefficiently delivers biomarkers productive to Biopharma. Massive infrastructures support sequence annotation, dominating the industry with the hope that cellular function can some day be inferred from sequence only. Yet, while proteomic advancements continue to better annotate sequence, functional annotation is necessary to advance compounds to the clinic. Such functional annotation lags far behind sequence annotation. New and better functional annotations for Proteomics is necessary to coincide with biopharma's core excellence in small molecule compound development. Here's why:                                                                                                                                                                                      

From the perspective of Biopharma, the 'omics' universe looks like the planet of the lost compounds. By this we mean, the thousands of compounds in the vault that are under-valued, under-utilized or otherwise cannot be commercialized. These include compounds that exhibit a cellular response (cytotoxicity to cancer cells for example), or compounds with known inhibition towards certain classes of enzymes (kinases for example), but with no suitable disease phenotype to modulate for therapeutic effect.                                                                                                                                                                                                                                          

But sequence annotation - the deliverable of conventional proteomics, is not particularly constituted to discover indications and to identify protein responsive markers for such compounds. This is because drugs work by modulating protein function. Many successful drugs are promiscuous, modulating multiple proteins at once, while toxicity can often come from modulation of off-targets. So understanding mechanism of action and indications discovery requires functional annotation. What the 'omics' industry largely disregards is the gorilla in the room for personalized medicine, which is that the same underlying sequence can have multiple conformations and functions, and different sequences sometimes perform the same or similar functions. Drug promiscuity compounds these problems. So new functional proteomic strategies are necessary.                          




ProFACT's proprietary platform, SeraFILE and its associated prospecting methods, fulfills this purpose delivering functional proteomic information that can complement and integrate with sequence annotation. By adapting our advances in separations technology to data-reporting infrastructure already available, functional proteomic characterizations can be more precisely resolved and annotated.  

To better understand SeraFILE™ or its three application areas, click on the links below:

SeraFILE™

Functional Proteome Prospecting™

Conformerics™

Rational Genome to Proteome Prospecting™

Partnerships and Services

We work collaboratively with our clients to customize applications to their research projects. Protocols developed are transferable to the client if desired. ProFACT maintains a high-throughput functional proteomics laboratory and network of 3rd parties for ancillary data requirements.


ProFACT works with clients on both a partnership and fee-for-service basis. Partnerships typically take the form of a negotiated contribution from both parties, with both participating in the results and discoveries. Fee-for-service relationships are client sponsored research whereby the client enjoys unimpeded, complete and exclusive rights, subject to no further compensation, to exploit all information and discoveries that arise from such research.


Confidentiality: ProFACT will not disclose any information obtained in the course of the services provided to clients without the express consent of the client. Confidentiality Agreements are often executed.

Talk to us about your drug development or system biology requirements. For more information, contact Matthew Kuruc at 732-230-3021 or mkuruc@profactproteomics.com.


Leaderboard

No leaderboard currently :(

View all
Most popular courses

Understanding Viral Diseases in Domestic Animals
Understanding Viral Diseases in Domestic Animals

This course provides comprehensive insights into viral diseases affecting domestic animals, including their epidemiology, clinical manifestations, diagnostic methods, prevention, and control strategies. Through a combination of lectures, case studies, and interactive discussions, participants will gain a deep understanding of various viral pathogens that pose threats to animal health and welfare.

Course Objectives:

  1. Identify common viral diseases affecting domestic animals.
  2. Understand the transmission dynamics and pathogenesis of viral infections.
  3. Recognize clinical signs and symptoms associated with different viral diseases.
  4. Learn about diagnostic techniques for viral disease detection and confirmation.
  5. Explore strategies for the prevention, control, and management of viral outbreaks.
  6. Discuss the economic and public health implications of viral infections in domestic animals.
Good Clinical Laboratory Practice (GCLP)  Sponsored by the Gentaur Group
Good Clinical Laboratory Practice (GCLP)  Sponsored by the Gentaur Group

We are grateful to the Gentaur Group for their support of this comprehensive Good Clinical Laboratory Practice (GCLP) course.

GCLP Expertise: Master the principles of Good Clinical Laboratory Practice (GCLP) for reliable data in clinical research.

Lab Operations: Refine your skills in managing laboratory processes to guarantee sample integrity and data quality.

Patient-Centric Research: Uphold ethical research practices and ensure patient safety in clinical trials.

Online Convenience: Learn at your own pace with this comprehensive online GCLP course.

Targeted Learning: Ideal for laboratory professionals and researchers seeking to advance their knowledge in GCLP.


View all
Newest courses

Advanced Concepts in Antibody-Drug Conjugates (ADCs)
Advanced Concepts in Antibody-Drug Conjugates (ADCs)

Course Overview:

This course is designed to provide an in-depth understanding of Antibody-Drug Conjugates (ADCs) to a scientific audience. The course will cover the fundamental principles, design and development, and therapeutic applications of ADCs. Participants will gain comprehensive knowledge of ADC mechanisms, the latest advancements in the field, and practical considerations for developing ADC-based therapies.

This course is sponsored by the Gentaur Group. We extend our heartfelt thanks to Gentaur for their generous support, which has made this course possible.


Understanding Viral Diseases in Domestic Animals
Understanding Viral Diseases in Domestic Animals

This course provides comprehensive insights into viral diseases affecting domestic animals, including their epidemiology, clinical manifestations, diagnostic methods, prevention, and control strategies. Through a combination of lectures, case studies, and interactive discussions, participants will gain a deep understanding of various viral pathogens that pose threats to animal health and welfare.

Course Objectives:

  1. Identify common viral diseases affecting domestic animals.
  2. Understand the transmission dynamics and pathogenesis of viral infections.
  3. Recognize clinical signs and symptoms associated with different viral diseases.
  4. Learn about diagnostic techniques for viral disease detection and confirmation.
  5. Explore strategies for the prevention, control, and management of viral outbreaks.
  6. Discuss the economic and public health implications of viral infections in domestic animals.
Fundamentals of Cell Biology
Fundamentals of Cell Biology

The "Fundamentals of Cellular Biology" course provides in-depth information about the basic components and functions of cells. This course is sponsored by Gentaur Group, a company that supplies reagents for biological research. The curriculum covers the fundamental molecules that make up cells, the processes by which cells reproduce, and how cells communicate with each other. You can register for the course today to begin learning about the essential building blocks of life.