CDC20 antibody - 100 µg

Host : Rabbit
Clonality: Polyclonal
Clone:
Isotype: IgG
Immunogen: cell division cycle 20 homolog
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular weight: 55 kDa
Uniprot: Q12834
Gene id: 991
Background: Required for full ubiquitin ligase activity of the anaphase promoting complex
cyclosome(APC
C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC
C ternary complex is inactive and in anaphase the CDC20-APC
C binary complex is active in degrading substrates. The CDC20-APC
C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC
C-induced degradation of NEUROD2 induces presynaptic differentiation.
Field of research: Cell Division and Proliferation, Metabolism
Storage conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze
thaw cycles.)
Applications: ELISA, WB, IHC
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Target: CDC20
Purification: Immunogen affinity purified
Reactivity: Human